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[Correlation between plasma level of endothelin-1 and heart remodeling in dilated cardiomyopathy]
Liliana Slătineanu1, Viviana Aursulesei, A Petriş
1Universitatea de Medicină i Farmacie "Gr.T. Popa" Iaşi, Facultatea de Medicină, Clinica I Medicală Cardiologiă.
Insights
Plasma endothelin-1 (ET-1) levels are elevated in patients with dilatative cardiomyopathy, correlating with heart failure severity and impaired cardiac function. These findings highlight ET-1
Area of Science:
- Cardiovascular Medicine
- Biochemistry
Context:
- The established link between plasma endothelin-1 (ET-1) and heart failure.
- Dilatative cardiomyopathy is characterized by significant morphological and hemodynamic alterations.
Purpose:
- To investigate the role of endothelin-1 in the progression of heart alterations in patients with dilatative cardiomyopathy.
- To correlate plasma ET-1 levels with echocardiographic and clinical parameters of heart failure.
Summary:
- This study included 71 patients with dilatative cardiomyopathy, assessing plasma ET-1 levels alongside comprehensive echocardiography and clinical evaluations.
- Elevated plasma ET-1 levels were observed in all patients and significantly correlated with NYHA class, reduced ejection fraction, and impaired cardiac output.
- Further associations were found between ET-1 and left ventricular volumes, regional wall motion abnormalities, and pulmonary artery pressure.
Impact:
- Provides evidence for endothelin-1's significant role in the pathophysiology of dilatative cardiomyopathy.
- Suggests endothelin-1 as a potential biomarker for heart failure severity and progression in this patient group.
- May inform future therapeutic strategies targeting the endothelin system in heart failure.
Unlabelled:
The link between plasma level of endothelin-1 (ET-1) and heart failure has been established. This study demonstrate the role of endothelin-1 in progression of morphological and haemodynamic alteration of heart in patients with dilatative cardiomyopathy.
Materials And Methods:
We included 71 patients with dilatative cardiomyopathy (ischemic and/or alcoholic)--36 men (50.7%) and 35 women (49.3%). We excluded patients who suffered from chronic renal failure, malignancies, systemic autoimmune disorders, liver cirrhosis. The echocardiography evaluated the chambers dimensions, valvular regurgitations, ejection and shortening fraction, systolic pulmonary artery pressure, cardiac output. All patients were assessed with endothelin-1 and usual hematological and biochemical tests, chest X-ray and electrocardiogram.
Results:
The plasma level of endothelin-1 was increased of all patients (5.2775 +/- 2.65 fmol/ml). The value of ET-1 was associated with NYHA class of congestive heart failure (p < 0.000002). All patients were ejection fraction low (< 40%) and it was strongly associated with high level of plasma ET-1 (p < 0.001). The shortening fraction was very low at 87.32% of patients (value was between 5% and 15%) and the relation with ET-1 was significantly (r = - 0.3911, p = 0.001). The same relation was between ET-1 and tele-diastolic and telesystolic left ventricular volume (p = 0.026, respectively, p = 0.001), regional kinetics alteration (p = 0.023), systolic pulmonary arterial pressure (p = 0.0001, r = 0.71) and cardiac output (p = 0.0234).
Conclusions:
The plasma level of endothelin-1 is high at all patients with dilatative cardiomyopathy. Functional and morphological heart alterations are tightly connected to the changes of the endothelin system.
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