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Evaluation of anti-inflammatory activity of alcoholic extract from Viola tricolor
Anca Toiu1, Alina Elena Pârvu, Ilioara Oniga
1Department of Botany, School of Pharmacy,"Iuliu Haţieganu" University of Medicine and Pharmacy Cluj-Napoca.
Aim:
Evaluation of anti-inflammatory actions of Viola tricolor aerial parts tincture.
Material And Method:
The anti-inflammatory activity of the tincture from Viola tricolor aerial parts was tested in acute inflammation induced with oil of turpentine (i.m. 0.6 ml/100 g b.w.) in male Wistar rats. The results were compared with those from a positive control group with experimental inflammation and with those of a group treated with diclofenac (30 mg/100 g b.w.). We tested the effects by measuring total leukocyte count and differential leukocyte count, a test of in vitro phagocytosis and by the evaluation of nitric oxide (NO) synthesis measuring the metabolites (nitrites and nitrates).
Results:
Viola tricolor extract (50 mg tincture/100 g b.w.) significantly reduced polymorphonuclear leukocytes and monocytes percentages and the activation of circulating phagocytes. Nitric oxide synthesis had a slight decrease.
Conclusion:
Viola tricolor extract had anti-inflammatory effect on bone marrow acute phase response.
