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Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
05:53

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty

Published on: July 24, 2013

[Variability in coronary risk assessment in HIV-infected patients]

Milagros García-Lázaro1, Antonio Rivero Román, Angela Camacho Espejo

  • 1Sección de Enfermedades Infecciosas, Hospital Universitario Reina Sofía, Córdoba, España. milagrosglazaro@telefonica.net

Medicina Clinica
|November 7, 2007
PubMed

Insights

Assessing coronary risk (CR) in HIV patients is crucial. The Framingham tables may overestimate CR compared to REGICOR, highlighting the need for accurate risk assessment tools in this population.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Public Health

Background:

  • Antiretroviral treatment in HIV-infected patients may increase coronary risk (CR).
  • Accurate CR assessment is vital for managing HIV patients.
  • Cardiovascular disease is a growing concern in the aging HIV population.

Purpose of the Study:

  • To compare the 10-year CR assessment between Framingham and REGICOR tables in HIV-infected patients.
  • To evaluate the prevalence of cardiovascular risk factors in this cohort.

Main Methods:

  • Prospective cohort study of 205 HIV-infected patients.
  • Calculation of 10-year CR using Framingham and REGICOR adapted tables.
  • Assessment of cardiovascular risk factors including smoking, dyslipidemia, hypertension, diabetes, lipodystrophy, obesity, and lifestyle.

Main Results:

  • Mean age was 41.4 years; most patients were on antiretrovirals with good immunological status.
  • High prevalence of current smoking (77.1%), dyslipidemia (29.3%), and sedentary lifestyle (50.7%).
  • Framingham tables indicated 12.9% of patients had >10% 10-year CR, versus 2.0% with REGICOR tables (p < 0.001).

Conclusions:

  • Framingham tables may overestimate coronary risk in HIV-infected patients.
  • Further research is needed to determine the most appropriate CR assessment method for HIV patients.
  • Caution is advised when estimating CR in HIV-infected individuals until validated methods are established.
Abstract

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