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What is Metabolism?00:52

What is Metabolism?

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Genomics02:02

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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Large Scale Non-targeted Metabolomic Profiling of Serum by Ultra Performance Liquid Chromatography-Mass Spectrometry (UPLC-MS)
07:34

Large Scale Non-targeted Metabolomic Profiling of Serum by Ultra Performance Liquid Chromatography-Mass Spectrometry (UPLC-MS)

Published on: March 14, 2013

Metabolomics.

Jeffrey R Idle1, Frank J Gonzalez

  • 1Institute of Pharmacology, 1st Faculty of Medicine, Charles University, 128 00 Praha 2, Czech Republic. jidle@lf1.cuni.cz

Cell Metabolism
|November 7, 2007
PubMed
Summary
This summary is machine-generated.

Metabolomics uses advanced NMR and MS to analyze small molecules in organisms. This technology is expanding systems biology and aiding studies in areas like xenobiotic metabolism.

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Last Updated: May 24, 2026

Large Scale Non-targeted Metabolomic Profiling of Serum by Ultra Performance Liquid Chromatography-Mass Spectrometry (UPLC-MS)
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Published on: March 14, 2013

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A Strategy for Sensitive, Large Scale Quantitative Metabolomics

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Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
11:02

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics

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Area of Science:

  • Biochemistry
  • Systems Biology
  • Analytical Chemistry

Background:

  • Metabolomics systematically identifies and quantifies all metabolites in biological samples.
  • Advanced analytical techniques like NMR spectroscopy and mass spectrometry (MS) have increased resolution for small molecule analysis.
  • Chemometric software enables simultaneous determination and comparison of numerous chemical entities.

Purpose of the Study:

  • To highlight recent advancements and applications of metabolomics.
  • To showcase the integration of small molecules into systems biology.
  • To review metabolomics studies in xenobiotic metabolism and genetically modified mice.

Main Methods:

  • Utilizing nuclear magnetic resonance (NMR) spectroscopy for metabolite identification.
  • Employing mass spectrometry (MS) for high-resolution metabolite quantitation.
  • Applying chemometric software for data analysis and comparison of chemical entities.

Main Results:

  • Expansion of small molecule biochemistry studies across bacteria, plants, and mammals.
  • Demonstration of metabolomics' utility in xenobiotic metabolism research.
  • Highlighting applications in genetically modified mouse models.

Conclusions:

  • Continued development of analytical platforms will accelerate metabolomics adoption.
  • Metabolomics is crucial for advancing systems biology by integrating small molecule data.
  • The field shows significant promise for diverse biological and biomedical research.