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Updated: Jul 10, 2026
11:17
Comparative Analysis of Human Growth Hormone in Serum Using SPRi, Nano-SPRi and ELISA Assays
Published on: January 7, 2016
The growth hormone secretagogue receptor
Conrad Russell Young Cruz1, Roy G Smith
1Translational Biology and Molecular Medicine Program, Baylor College of Medicine, Houston, TX 77030, USA.
Vitamins and Hormones
|November 7, 2007
Summary
Ghrelin, a neuroendocrine hormone, impacts aging and various bodily systems via the growth hormone secretagogue receptor (GHSR). Further research into GHSR subtypes and agonists may yield treatments for age-related diseases.
Area of Science:
- Neuroendocrinology
- Molecular Biology
- Gerontology
Background:
- Ghrelin is a neuroendocrine hormone with diverse physiological activities.
- Its primary mechanism involves the growth hormone secretagogue receptor (GHSR) type 1a.
- GHSR is widely expressed, indicating ghrelin's broad systemic influence.
Purpose of the Study:
- To explore the role of ghrelin and GHSR in aging mechanisms.
- To identify potential clinical applications of GHSR characterization in age-related conditions.
- To investigate emerging evidence for additional GHSR subtypes and agonists.
Main Methods:
- Review of existing literature on ghrelin and GHSR.
- Analysis of GHSR expression patterns across various tissues.
- Examination of ghrelin's impact on the GH/IGF-1 axis and metabolic systems.
Main Results:
- GHSR's extensive distribution and role in key physiological systems suggest involvement in aging.
- Ghrelin signaling influences the GH/IGF-1 axis, neuroendocrine, and metabolic functions.
- Emerging research indicates potential for novel GHSR subtypes and ligands.
Conclusions:
- Ghrelin and GHSR play a significant role in aging and age-related diseases.
- Further characterization of GHSR and its ligands could lead to therapeutic interventions for anorexia, cardiovascular disease, cancer, and immune dysfunction.
- The full scope of ghrelin-GHSR signaling in physiology and disease is still under investigation.
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