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An Orthotopic Murine Model of Human Prostate Cancer Metastasis
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Published on: September 18, 2013

Ghrelin and prostate cancer.

Fabio Lanfranco1, Matteo Baldi, Paola Cassoni

  • 1Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Turin, 10126, Turin, Italy.

Vitamins and Hormones
|November 7, 2007
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Summary

Ghrelin, a stomach hormone, and its receptors are found in prostate cancer cells. This suggests the ghrelin system may play a role in this malignancy.

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Area of Science:

  • Endocrinology
  • Oncology
  • Molecular Biology

Background:

  • Ghrelin is a peptide hormone primarily produced in the stomach.
  • It acts as a ligand for the growth hormone secretagogue receptor type 1a (GHSR1a).
  • Ghrelin influences growth hormone release, appetite, and has roles in tissue development and cancer cell proliferation.

Purpose of the Study:

  • To investigate the expression of ghrelin and its receptors in prostate cancer.
  • To explore the potential functional role of the ghrelin system in prostate cancer cell lines.

Main Methods:

  • Analysis of ghrelin and GHSR expression at mRNA and protein levels in cancer cells and tissues.
  • Examination of ghrelin receptor subtypes, including GHSR1a and GHSR1b.
  • Assessment of ghrelin binding sites independent of acylation.

Main Results:

  • Ghrelin and its receptors are expressed in various cancer types, including prostate cancer.
  • Coexpression of ghrelin and its receptors in cancer cell lines suggests autocrine/paracrine functions.
  • Prostate cancer tissues and cell lines show evidence of ghrelin system components.

Conclusions:

  • The ghrelin system is implicated in the pathophysiology of several human cancers.
  • Ghrelin and its receptors are present in prostate cancer, indicating a potential role in tumorigenesis.
  • Further research is warranted to elucidate the specific functional significance of the ghrelin system in prostate cancer.