Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

VFDB 2008 release: an enhanced web-based resource for comparative pathogenomics.

Jian Yang1, Lihong Chen, Lilian Sun

  • 1State Key Laboratory for Molecular Virology and Genetic Engineering, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100176, China.

Nucleic Acids Research
|November 7, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Glassy dynamics and mechanical response in dense fluids of soft repulsive spheres. I. Activated relaxation, kinetic vitrification, and fragility.

The Journal of chemical physics·2011
Same author

Climatic reconstruction at the Miocene Shanwang basin, China, using leaf margin analysis, CLAMP, coexistence approach, and overlapping distribution analysis.

American journal of botany·2011
Same author

Novel candidate colorectal cancer biomarkers identified by methylation microarray-based scanning.

Endocrine-related cancer·2011
Same author

Stress and strain analysis of contractions during ramp distension in partially obstructed guinea pig jejunal segments.

Journal of biomechanics·2011
Same author

Role of Gα(12)- and Gα(13)-protein subunit linkage of D(3) dopamine receptors in the natriuretic effect of D(3) dopamine receptor in kidney.

Hypertension research : official journal of the Japanese Society of Hypertension·2011
Same author

Transarticular screw and C1 hook fixation for os odontoideum with atlantoaxial dislocation.

World neurosurgery·2011
Same journal

Neurochondrin promotes U5 snRNP maturation by regulating AAR2 release from PRPF8.

Nucleic acids research·2026
Same journal

Elongationless start-stop elements are stress-resilient translation gates that are more repressive than uTranslons.

Nucleic acids research·2026
Same journal

Evolution of the ribosomal exit tunnel through the eyes of the nascent chain.

Nucleic acids research·2026
Same journal

Enhancing the performance and interpretability of epigenetic clocks.

Nucleic acids research·2026
Same journal

FABIAN-variant 2026: improved prediction of the effects of DNA variants on transcription factor binding.

Nucleic acids research·2026
Same journal

Structural and biochemical characterization of Grimontia hollisae thermostable direct hemolysin with DNA reveals first Vibrio hemolysin with nuclease activity.

Nucleic acids research·2026
See all related articles

The Virulence Factor Database (VFDB) was updated in 2008 to enhance pathogenomic research. New features facilitate comparative genomics for discovering bacterial virulence factors and understanding pathogenesis.

Area of Science:

  • Microbiology
  • Bioinformatics
  • Genomics

Background:

  • The Virulence Factor Database (VFDB) was established in 2004 to catalog bacterial virulence factors (VFs).
  • The availability of complete bacterial genome sequences enables comparative genomics for identifying virulence determinants.
  • Pathogenomic research requires comprehensive data on virulence genes and their organization.

Purpose of the Study:

  • To upgrade the VFDB with enhanced features for comparative pathogenomics.
  • To facilitate the discovery of novel virulence determinants through genome analysis.
  • To improve understanding of bacterial pathogenesis and evolution.

Main Methods:

  • Incorporation of detailed tabular comparisons of virulence gene composition across bacterial genera.

Related Experiment Videos

  • Implementation of multiple alignments and statistical analyses for homologous VFs.
  • Development of graphical tools for comparing genomic organization of virulence genes.

    • Main Results:

    • The VFDB 2008 release offers advanced comparative analysis tools for bacterial genomes.
    • New features enable detailed examination of virulence factor diversity and genomic context.
    • Enhanced data presentation supports in-depth pathogenomic studies.

    Conclusions:

    • The upgraded VFDB 2008 release provides powerful tools for comparative pathogenomics.
    • Comparative analysis of VFs aids in understanding virulence evolution and pathogenesis.
    • The database supports the development of new therapeutic and preventive strategies against bacterial pathogens.