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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Blood pressure measures and risk of chronic kidney disease in men

Elke S Schaeffner1, Tobias Kurth, Thomas S Bowman

  • 1Department of Medicine, Charité Campus Virchow, Berlin, Germany.

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
|November 7, 2007
PubMed

Insights

Systolic blood pressure (SBP) and pulse pressure (PP) best predict chronic kidney disease (CKD) risk. SBP is most clinically useful for predicting CKD, requiring no additional calculations.

Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Epidemiology

Background:

  • High blood pressure (BP) is linked to reduced kidney function.
  • The optimal BP measure for predicting kidney disease remains unclear.

Purpose of the Study:

  • To compare systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse pressure (PP), and mean arterial pressure (MAP) in predicting chronic kidney disease (CKD) risk.
  • To identify the most effective BP measure for early identification of kidney impairment.

Main Methods:

  • Prospective follow-up of 8093 male participants over 14 years.
  • BP values averaged from baseline and 24-month questionnaires; creatinine measures after 14 years.
  • Logistic regression used to assess associations between BP measures and CKD (eGFR <60 mL/min/1.73 m²).

Main Results:

  • 12.8% of participants developed CKD over 14 years.
  • SBP and PP demonstrated the strongest predictive ability for CKD, with equal efficacy.
  • Increased SBP, PP, and MAP were significantly associated with higher CKD risk.

Conclusions:

  • Systolic blood pressure (SBP) and pulse pressure (PP) are superior predictors of chronic kidney disease (CKD) compared to DBP and MAP.
  • SBP is identified as the most clinically practical predictor due to its simplicity.
  • Combining different BP measures did not significantly enhance CKD prediction accuracy.
Abstract

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