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A history of association mapping
1Human Genetics Division, Southampton General Hospital, UK.
Methods in Molecular Biology (Clifton, N.J.)
|November 7, 2007
Summary
This review traces the historical development of association mapping theory, highlighting its foundational role in current genetic research and exciting advancements.
Area of Science:
- Genetics and Bioinformatics
- Statistical Genetics
Background:
- The theoretical underpinnings of association mapping have evolved since the early 20th century.
- Understanding this historical context is crucial for appreciating current research.
Observation:
- The field of association mapping has undergone significant theoretical advancements.
- These developments are directly linked to foundational theories established over the past century.
Findings:
- This review provides a historical overview of association mapping theory.
- It contextualizes current exciting developments within this established theoretical framework.
Implications:
- Provides a foundational understanding for researchers in statistical genetics and bioinformatics.
- Highlights the continuity and evolution of genetic association studies.
