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Detection of Homologous Recombination Intermediates via Proximity Ligation and Quantitative PCR in Saccharomyces cerevisiae
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Linkage disequilibrium maps and location databases.

William Tapper1

  • 1Human Genetics Division, Southampton General Hospital, UK.

Methods in Molecular Biology (Clifton, N.J.)
|November 7, 2007
PubMed
Summary

Linkage Disequilibrium Units (LDUs) maps offer a novel approach for complex trait association studies. These maps capture recombination, mutation, selection, drift, and historical population bottlenecks, improving genetic analyses.

Area of Science:

  • Population Genetics
  • Genomic Analysis
  • Bioinformatics

Background:

  • Association mapping for complex traits relies on understanding linkage disequilibrium (LD) patterns.
  • Existing methods may not fully capture the historical demographic factors influencing LD.

Purpose of the Study:

  • To introduce and describe Linkage Disequilibrium Units (LDUs) maps.
  • To provide methodology for constructing LDU maps and discuss their applications.

Main Methods:

  • Utilizing a modified isolation-by-distance model (Malecot's model).
  • Quantifying LD patterns influenced by recombination, mutation, selection, genetic drift, and population bottlenecks.

Main Results:

  • LDU maps provide an additive metric analogous to linkage maps, aiding association studies.

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  • LDU maps uniquely reflect historical population bottlenecks, explaining variations in LD patterns.

    • Conclusions:

    • LDU maps enhance association mapping by incorporating historical demographic effects.
    • LDU maps have applications beyond association studies and can be integrated into databases.