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Related Experiment Video

Updated: Jul 10, 2026

Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression

Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression

Published on: May 19, 2015

Depression, prolactin and dissociated mind.

Petr Bob¹, P G Fedor-Freybergh, Marek Susta

¹Department of Psychiatry, 1st Faculty of Medicine, Charles University, Prague, Czech Republic. petrbob@netscape.net

Neuro Endocrinology Letters

|November 7, 2007

Summary

Serum prolactin levels in depressed patients correlate with dissociative symptoms, suggesting a link to passive coping mechanisms. Traumatic stress symptoms did not show a significant relationship with prolactin levels.

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Area of Science:

Neuroendocrinology
Psychiatry
Clinical Psychology

Background:

The hypothalamus-pituitary-adrenal (HPA) axis is typically dysregulated in response to traumatic stress and dissociation.
Understanding neuroendocrine markers associated with these conditions is crucial for effective treatment.

Purpose of the Study:

To investigate the relationship between basal serum prolactin levels and dissociative symptoms.
To examine the association between basal serum prolactin levels and symptoms of traumatic stress in patients with unipolar depression.

Main Methods:

Assessed 25 inpatients diagnosed with unipolar depression using dissociation (DES) and traumatic symptom (TSC-40) scales.
Measured basal serum prolactin levels using standard biochemical analytical methods.

Main Results:

A significant positive correlation was observed between serum prolactin levels and dissociative symptoms (r=0.52, p=0.004).
No significant correlation was found between serum prolactin levels and traumatic symptoms as measured by the TSC-40 (r=0.31, p=0.07).

Conclusions:

Serum prolactin levels in patients with unipolar depression are associated with dissociative symptoms.
This association may be attributed to passive coping mechanisms contributing to dissociation.