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Updated: Jul 10, 2026

Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy
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Sentinel lymph node evaluation does not improve staging accuracy in colon cancer.

Sherry J Lim1, Barry W Feig, Huamin Wang

  • 1Department of Surgical Oncology, The University of Texas, M. D. Anderson Cancer Center, 1515 Holcombe Blvd., P.O. Box 301402, Houston, Texas, 77230-1402, USA.

Annals of Surgical Oncology
|November 7, 2007
PubMed
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Sentinel lymph node (SLN) evaluation for colon cancer has low sensitivity and a high false-negative rate. This technique does not improve the accuracy of nodal staging in patients with colon cancer.

Area of Science:

  • Oncology
  • Surgical Pathology

Background:

  • Lymph node status is a critical prognostic indicator in colorectal cancer.
  • Sentinel lymph node (SLN) evaluation for nodal staging in colon cancer is debated.
  • This study assesses the accuracy of SLN evaluation in resectable colon cancer.

Purpose of the Study:

  • To evaluate the sensitivity, predictive value, and accuracy of SLN evaluation for nodal staging in colon cancer.
  • To determine if SLN evaluation improves nodal staging accuracy compared to traditional methods.

Main Methods:

  • Prospective cohort study of SLN evaluation in 120 colon cancer patients (September 1998 - April 2006).
  • SLN mapping using isosulfan blue dye and (m99)Tc sulfur colloid.
  • SLNs analyzed by hematoxylin and eosin (HE) staining, with additional immunohistochemical (IHC) staining for pancytokeratin and MOC31 if HE was negative.

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Main Results:

  • SLNs were identified in 99% of patients.
  • HE staining detected nodal metastases in 40% of patients.
  • SLN evaluation had a sensitivity of 59% for detecting metastases, with a 41% false-negative rate. IHC identified an additional 7% of cases with metastases.
  • Positive IHC status did not impact overall survival (P = .41).

Conclusions:

  • SLN evaluation demonstrates low sensitivity and a high false-negative rate in colon cancer.
  • The technique does not enhance the accuracy of nodal staging for colon cancer.
  • The clinical significance of IHC-positive SLNs requires further investigation.