[Leukofibrinolysis enhanced by leukocyte adhesion to a clot with antifibrin antibodies]

The possibility of intensifying the thrombolytic action of circulating leukocytes was studied in experiments in vitro. Sixty-five cells per unit of gel surface adhered to an intact fibrin clot. Treatment of the fibrin clot with fibrinogen antiserum increased the number of adhering cells to 863. Immune gamma-fraction and purified antifibrin antibodies caused similar stimulation of adhesion (931 and 716 cells, respectively). In contrast, control serum from nonimmunized animals reduced leukocyte adhesion. It is concluded that the fibrinolytic activity of leukocytes may be increased.