[The possible reasons for an increase in the concentration of middle-weight molecules in pathology]

Human plasma and blood were treated by kaolin, thromboplastin, streptokinase, phytohemagglutinin, hydrogen peroxide, and Fe2+. An increase in the amount of median-mass substances was found after incubation. The obtained data showed that activation of limited proteolysis, immunity, and peroxidation could be the cause of increase of median-mass substances in pathological conditions.