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Updated: Jul 10, 2026

Förster Resonance Energy Transfer Mapping: A New Methodology to Elucidate Global Structural Features
Published on: March 16, 2022
The stargazin C terminus encodes an intrinsic and transferable membrane sorting signal
Matthew A Bedoukian1, Jennifer D Whitesell1, Erik J Peterson1
1Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80523-1617.
Abstract:
Activity-dependent plasticity of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors is regulated by their auxiliary subunit, stargazin. Association with stargazin enhances alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor surface expression and modifies the receptor's biophysical properties. Fusing the cytoplasmic C terminus of stargazin to the C-terminal domains of either GluR1 or the gonadotropin-releasing hormone receptor permits efficient trafficking from the endoplasmic reticulum and sorting to the basolateral membrane without altering other properties of either receptor.
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