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A tyrosinase inhibitor, Daedalin A, from mycelial culture of Daedalea dickinsii
Keiji Morimura1, Chihiro Yamazaki, Yasunao Hattori
1Interdisciplinary Graduate School of Science and Technology, Shinshu University, Nagano 399-4598, Japan.
Abstract:
A chromene-type compound, daedalin A (1), was isolated from mycelial culture broth of Daedalea dickinsii. Based on spectroscopic data, the structure of 1 was found to be (2R)-6-hydroxy-2-hydroxymethyl-2-methyl-2H-chromene. Daedalin A (1) strongly inhibited the activity of tyrosinase (IC(50): 194 muM). In addition, 1 also showed 1,1-diphenyl-2-picrylhydrazyl scavenging activity (IC(50): 16.9 microM) and superoxide anion scavenging activity (IC(50): 28.5 microM).
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