Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Epidermal homeostasis: do committed progenitors work while stem cells sleep?

Philip Jones1, Benjamin D Simons

  • 1Philip Jones is at the MRC Cancer Cell Unit, Hutchison/MRC Research Centre, Cambridge, CB2 2XZ, UK. phj20@hutchison-mrc.cam.ac.uk

Nature Reviews. Molecular Cell Biology
|November 8, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Resuscitation Quality Improvement Program for CPR Training and Cardiac Arrest Survival in Hospitals.

JAMA cardiology·2026
Same author

The temporal architecture of the seminiferous epithelial cycle revealed by spatial transcriptomics.

Cell·2026
Same author

Temporal Trends in Direct-Acting Oral Anticoagulants Use Among Patients at Extremes of Body Weight: Insight From PINNACLE Registry.

Mayo Clinic proceedings. Innovations, quality & outcomes·2026
Same author

Early fibrotic niches establish tumour-permissive microenvironments.

Nature·2026
Same author

Hospital-Level Variability in NSTEMI Management: Findings From the NCDR Chest Pain-MI Registry.

Circulation. Cardiovascular interventions·2026
Same author

Exploring an enhanced role of the pharmacy technician in cancer services within the uk independent sector.

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners·2026
Same journal

Single-cell evidence for PANoptosome complexes.

Nature reviews. Molecular cell biology·2026
Same journal

Reply to 'Single-cell evidence for PANoptosome complexes'.

Nature reviews. Molecular cell biology·2026
Same journal

Plucking cellular ribosomes with Ribo-Tweezer.

Nature reviews. Molecular cell biology·2026
Same journal

COPII meets autophagy at the ER membrane.

Nature reviews. Molecular cell biology·2026
Same journal

Diapause presses pause on life's developmental and ageing clock.

Nature reviews. Molecular cell biology·2026
Same journal

Histone acetylation at the dawn of gene regulation.

Nature reviews. Molecular cell biology·2026
See all related articles

Murine epidermis homeostasis can be maintained by committed progenitor cells, not just long-lived stem cells. This finding challenges the traditional view of tissue regeneration and cellular maintenance in adult tissues.

Area of Science:

  • Developmental Biology
  • Stem Cell Biology
  • Tissue Homeostasis

Background:

  • The epidermis relies on stem cells for long-term tissue maintenance.
  • Cellular homeostasis in adult tissues is thought to depend on stem cell proliferation.

Purpose of the Study:

  • To investigate the role of different cell populations in murine epidermis maintenance.
  • To challenge the established dogma regarding stem cell requirements for tissue homeostasis.

Main Methods:

  • In vivo cell fate tracking in murine epidermis.
  • Analysis of progenitor and stem cell populations dynamics.

Main Results:

  • A committed progenitor cell population can sustain adult murine epidermis long-term.

Related Experiment Videos

  • This maintenance occurs independently of a long-lived, self-renewing stem cell population.

    • Conclusions:

    • Stem cell proliferation may not be universally required for epidermal homeostasis.
    • Findings have significant implications for understanding tissue physiology and diseases related to regeneration.