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Related Concept Videos

Brain Imaging01:14

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
Positron Emission Tomography01:29

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...
Drug Discovery: Overview01:26

Drug Discovery: Overview

Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
Imaging Studies I: CT and MRI01:14

Imaging Studies I: CT and MRI

Introduction: MRI and CT scans are crucial advancements in medical imaging techniques, playing a vital role in diagnosing conditions related to the gastrointestinal (GI) system. Each scan serves distinct purposes, targets specific areas, and requires unique nursing duties.
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...

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Related Experiment Video

Updated: Jul 10, 2026

Preclinical Positron Emission Tomography with Body Conforming Animal Molds for Cloud-Based Automated Image Analysis in Mice
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Preclinical Positron Emission Tomography with Body Conforming Animal Molds for Cloud-Based Automated Image Analysis in Mice

Published on: October 25, 2024

Imaging as a tool in drug development.

Thomas Strack1

  • 1Pfizer Inc., New York, New York 10017, USA. thomas.strack@pfizer.com

Drugs of Today (Barcelona, Spain : 1998)
|November 8, 2007
PubMed
Summary
This summary is machine-generated.

Functional imaging, including Positron Emission Tomography (PET) and Magnetic Resonance Imaging (MRI), is revolutionizing drug development. These advanced medical imaging techniques can accelerate clinical trials and improve patient treatment, with regulatory guidelines pending.

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Preclinical Positron Emission Tomography with Body Conforming Animal Molds for Cloud-Based Automated Image Analysis in Mice
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Multimodal Cross-Device and Marker-Free Co-Registration of Preclinical Imaging Modalities

Published on: October 27, 2023

Area of Science:

  • Medical imaging
  • Pharmaceutical drug development
  • Clinical practice

Background:

  • Exploratory medical imaging technologies have significantly advanced in recent decades.
  • Functional imaging is poised to transform medicine and pharmaceutical research.
  • Positron Emission Tomography (PET) and Magnetic Resonance Imaging (MRI) are leading technologies in clinical drug development.

Purpose of the Study:

  • To highlight the revolutionary impact of functional imaging in medicine and drug development.
  • To discuss the current competitive landscape of medical imaging technologies.
  • To explore the role of PET and MRI in accelerating drug development and improving patient care.

Main Methods:

  • Review of advancements in medical imaging technologies.
  • Analysis of the application of functional imaging in drug discovery and development.
  • Discussion of the utility and limitations of PET and MRI data in clinical trials.

Main Results:

  • PET and MRI are valuable adjuncts in clinical drug development, aiding in proof-of-concept and early efficacy trials.
  • Data from PET and MRI currently serve as biomarkers but are insufficient for regulatory approval alone.
  • The U.S. Food and Drug Administration (FDA) is developing guidelines for new imaging methods.

Conclusions:

  • Judicious use of PET and MRI can accelerate high-risk clinical trial programs.
  • New imaging methods have the potential to expedite drug development.
  • These technologies may lead to improved treatment strategies for individual patients.