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Synthesis of some N4-substituted isatin-3-thiosemicarbazones
H Pervez1, M S Iqbal, M Y Tahir
1Department of Chemistry, Bahauddin Zakariya University, Multan, 60800, Pakistan. pdhpervez@hotmail.com
Abstract:
In this article, we describe a simple and new method for the synthesis of some N4-substituted isatin-3-thiosemicarbazones based on the reactions of the common intermediate, methyl 2-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)-1-hydrazinecarbodithioate, prepared by condensing isatin with methyl 1-hydrazinecarbodithioate, and the readily available amines in essentially a one-step reaction. The synthesized thiosemicarbazones were fully characterized by their physical, analytical, and spectral (IR, 1H-NMR, EIMS) data.
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