Recent developments in the chemistry, analysis and control for the manufacture of therapeutic-grade synthetic
Nanda D Sinha1, Dennis P Michaud
1Archemix Corporation, 300 Third Street, Cambridge, MA 02142, USA. Nanda.Sinha@comcast.net
Current Opinion in Drug Discovery & Development
|November 8, 2007
Abstract:
Significant developments in oligonucleotide chemistry, which occurred between 1980 and 2000, led to several oligonucleotide-based therapeutics entering clinical trials. Improvements in synthesis and purification methods, along with analytical techniques have facilitated the large-scale manufacture of high quality oligonucleotides to support these clinical trials.
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