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Updated: Jul 10, 2026
08:21
A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis
Published on: October 26, 2020
[Atherosclerotic renal artery stenosis]
1II. Interne Abteilung für Kardiologie, Klinikum Wels, Wels. martin.rammer@klinikum-wels.at
Deutsche Medizinische Wochenschrift (1946)
|November 8, 2007
Summary
Atherosclerosis causes 90% of renal artery stenosis, leading to hypertension and kidney damage. Treatment involves medication, risk factor modification, and revascularization for severe cases.
Area of Science:
- Cardiovascular Medicine
- Nephrology
Context:
- Atherosclerotic renal artery stenosis (ARAS) is a significant cause of secondary hypertension and ischemic nephropathy.
- Prevalence of ARAS is higher in patients with resistant hypertension, coronary, or peripheral arterial disease.
Purpose:
- To review the epidemiology, diagnosis, and management of atherosclerotic renal artery stenosis.
- To highlight the role of medical therapy and revascularization in ARAS patients.
Summary:
- Atherosclerosis accounts for 90% of renal artery stenosis cases.
- Diagnosis involves contrast renal arteriography (gold standard) and non-invasive methods like MR angiography, CT angiography, and duplex ultrasonography.
- Management includes medical therapy (hypertension control, antiplatelet therapy, risk factor modification) and revascularization (percutaneous angioplasty with stenting) for select patients.
Impact:
- ARAS management impacts cardiovascular and renal outcomes.
- Effective treatment can prevent progression of kidney disease and reduce cardiovascular events.
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