Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Pericarditis II: Clinical Features and Diagnostic Tests

Pericarditis II: Clinical Features and Diagnostic Tests

Pericarditis is distinguished by inflammation of the pericardium, the fibrous sac that encases the heart. It can be acute, lasting less than six weeks, or chronic, persisting for over three months. Understanding its clinical manifestations and diagnostic findings is crucial for timely and effective management.Clinical ManifestationsWhile pericarditis can be asymptomatic, it usually presents with characteristic symptoms such as:Chest Pain: The most characteristic symptom of pericarditis is chest...

Pericarditis III: Medical Management

Pericarditis III: Medical Management

The primary objectives of managing pericarditis are to determine the underlying cause, provide effective therapy for treatment and symptom relief, and promptly detect signs and symptoms of cardiac tamponade. The following outlines the essential aspects of medical management for pericarditis:ObjectivesDetermine the Cause: Identifying the underlying cause of pericarditis is crucial for targeted treatment. Causes include viral infections, autoimmune diseases, post-cardiac injury syndrome, and...

Pericarditis I: Introduction

Pericarditis I: Introduction

Pericarditis is defined as the inflammation of the pericardium, the thin, sac-like membrane surrounding the heart. This condition can cause significant chest pain and other symptoms, often necessitating medical intervention. The pericardium has two layers: the inner visceral layer and the outer parietal layer, separated by a small amount of fluid that reduces friction during heartbeats.Types of PericarditisPericarditis can be classified into several types based on the duration and nature of the...

Pericarditis IV: Nursing Management

Pericarditis IV: Nursing Management

Pericarditis, an inflammation of the pericardium, necessitates diligent nursing management to ensure effective patient care and recovery. The initial step in managing pericarditis is a comprehensive patient medical assessment.The patient reports chest pain aggravated by breathing, coughing, and swallowing, which worsens when lying supine. The pain often improves when sitting up and leaning forward. Additional symptoms may include fever, malaise, and, in severe cases, signs of heart failure.

Cardiomyopathy II: Dilated Cardiomyopathy

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...

Cytotoxic Edema: Pathophysiology

Cytotoxic Edema: Pathophysiology

Cytotoxic edema is a form of cerebral edema characterized by intracellular swelling of neurons, astrocytes, and other glial cells. It develops when the mechanisms responsible for maintaining ionic gradients across the cell membrane become impaired. Under normal physiological conditions, the sodium–potassium ATPase actively transports sodium ions out of the cell and potassium ions into the cell, preserving osmotic balance and enabling electrical signaling. This pump requires a continuous supply...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Multidisciplinary meeting for breast cancer care: EUSOMA recommendations for optimization.

Breast (Edinburgh, Scotland)·2026

Same author

The role of germline mutations in non-small cell lung cancer: A systematic review of emerging genetic drivers and clinical implications.

Critical reviews in oncology/hematology·2026

Same author

Prognostic significance of circulating tumor DNA in early breast cancer: a systematic review and meta-analysis.

Breast cancer research and treatment·2026

Same author

READY: REAl-world Data from an Italian compassionate use program of avelumab first-line maintenance for locallY advanced or metastatic urothelial carcinoma.

ESMO real world data and digital oncology·2026

Same author

Activity of chemotherapy in mesenchymal chondrosarcoma: a multicentre retrospective analysis within the Italian Sarcoma Group network.

ESMO open·2026

Same author

Medical decision analysis for personalized oncology at the patient bedside.

Tumori·2026

Search research articles

Related Experiment Video

Updated: Jul 10, 2026

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo

Published on: May 16, 2020

Docetaxel induced pericardial effusion.

B Vincenzi¹, D Santini, A M Frezza

¹Medical Oncology, University Campus Bio-Medico, Rome, Italy. b.vincenzi@unicampus.it

Journal of Experimental & Clinical Cancer Research : CR

|November 9, 2007

Summary

Docetaxel, a key anticancer drug, can cause fluid retention, often manifesting as edema or pleural effusion. This report details two cases of recurrent pericardial effusion following docetaxel treatment, highlighting a potential cumulative toxicity.

More Related Videos

Carotid Artery Infusions for Pharmacokinetic and Pharmacodynamic Analysis of Taxanes in Mice

Carotid Artery Infusions for Pharmacokinetic and Pharmacodynamic Analysis of Taxanes in Mice

Published on: October 27, 2014

Related Experiment Videos

Last Updated: Jul 10, 2026

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo

Published on: May 16, 2020

Carotid Artery Infusions for Pharmacokinetic and Pharmacodynamic Analysis of Taxanes in Mice

Carotid Artery Infusions for Pharmacokinetic and Pharmacodynamic Analysis of Taxanes in Mice

Published on: October 27, 2014

Area of Science:

Oncology
Pharmacology
Cell Biology

Background:

Docetaxel is a vital chemotherapeutic agent derived from Taxus Brevifolia.
Its primary mechanism involves microtubule stabilization, leading to mitotic arrest and cancer cell death.
Neutropenia is a principal dose-limiting toxicity, with hypersensitivity reactions and dermatitis as common acute side effects.

Observation:

Fluid retention is a recognized, cumulative dose-limiting toxicity of docetaxel, though its pathophysiology remains unclear.
Manifestations typically include edema and pleural effusion.
This report presents two cases of patients experiencing recurrent pericardial effusion after docetaxel administration.

Findings:

The two cases illustrate a potential, albeit uncommon, manifestation of docetaxel-induced fluid retention.
Recurrent pericardial effusion may represent a cumulative toxicity in patients undergoing multiple treatment cycles.
Further investigation into the specific mechanisms underlying docetaxel-related fluid accumulation is warranted.

Implications:

Understanding the full spectrum of docetaxel toxicities is crucial for patient management and treatment optimization.
Recognizing pericardial effusion as a potential side effect can aid in early diagnosis and intervention.
This case series may prompt further research into the cardiotoxic effects of docetaxel.