Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dauer.

Patrick J Hu1

  • 1Life Sciences Institute, University of Michigan, Division of Hematology/Oncology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA. pathu@umich.edu

Wormbook : the Online Review of C. Elegans Biology
|November 9, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Strength in Numbers: Leveraging Mentorship Teams to Support Medical Student Research in Turbulent Research Environments.

Medical science educator·2026
Same author

Paving the physician-scientist career path: from grassroots gathering to national forum.

JCI insight·2025
Same author

Is it time to reduce the length of postgraduate training for physician-scientists in internal medicine?

JCI insight·2024
Same author

Structural insights into the career path between pre- and postgraduate physician-scientist training programs.

eLife·2023
Same author

Pearls of wisdom for aspiring physician-scientist residency applicants and program directors.

JCI insight·2022
Same author

Microbiome: Insulin signaling shapes gut community composition.

Current biology : CB·2021
Same journal

Caenorhabditis nomenclature.

WormBook : the online review of C. elegans biology·2018
Same journal

Tubulins in C. elegans.

WormBook : the online review of C. elegans biology·2018
Same journal

History of research on C. elegans and other free-living nematodes as model organisms.

WormBook : the online review of C. elegans biology·2017
Same journal

Development, structure, and maintenance of C. elegans body wall muscle.

WormBook : the online review of C. elegans biology·2016
Same journal

Working with dauer larvae.

WormBook : the online review of C. elegans biology·2016
Same journal

Small GTPases.

WormBook : the online review of C. elegans biology·2016
See all related articles

C. elegans larvae enter dauer arrest to survive harsh conditions. Researchers have identified key dauer pheromones, regulatory genes, and the DAF-12 receptor, advancing understanding of this developmental process.

Area of Science:

  • Developmental Biology
  • Genetics
  • Molecular Biology

Background:

  • C. elegans larvae exhibit dauer arrest, a survival response to adverse environmental conditions.
  • Significant progress has been made in elucidating the signaling pathways and molecular mechanisms governing this developmental transition.

Purpose of the Study:

  • To summarize the current understanding of dauer arrest in C. elegans.
  • To highlight key discoveries in signaling pathways, gene regulation, and receptor identification.
  • To identify remaining questions regarding the mechanistic underpinnings of dauer arrest.

Main Methods:

  • Purification, identification, and synthesis of dauer pheromone.
  • Genetic screens to isolate and identify dauer regulatory genes.

Related Experiment Videos

  • Identification of physiologic ligands for the DAF-12 nuclear receptor.
  • Genomic analysis of dauer arrest pathways.

    • Main Results:

    • Dauer pheromone, a key signal for dauer arrest, has been characterized.
    • The molecular identities of most dauer regulatory genes are now known.
    • Physiologic ligands for the central DAF-12 receptor have been identified.
    • New regulatory genes have been discovered through Hid phenotype and enhancer screens.
    • Genomic studies reveal the importance of pathway crosstalk in dauer regulation.

    Conclusions:

    • Decades of research have significantly advanced the understanding of C. elegans dauer arrest.
    • Key molecular players, including pheromones, genes, and the DAF-12 receptor, have been identified.
    • Despite progress, critical questions about the mechanistic details of dauer arrest persist.