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Published on: July 12, 2018
Psammaplysenes C and D, cytotoxic alkaloids from Psammoclemma sp
Malcolm S Buchanan1, Anthony R Carroll, Rama Addepalli
1Eskitis Institute, Griffith University, Brisbane, Queensland 4111, Australia.
Journal of Natural Products
|November 9, 2007
Abstract:
The sponge Psammoclemma sp. was investigated as part of our studies to discover P2X 7 receptor antagonists for the treatment of inflammatory disease. The biological activity of this extract was found to be due to the cytotoxicity of two new bromotyrosine alkaloids, psammaplysenes C (1) and D (2), and not P2X 7-specific activity. Their structures were determined by 1D and 2D NMR spectroscopy.
