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Updated: Jul 10, 2026
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Free Radicals in Chemical Biology: from Chemical Behavior to Biomarker Development
Published on: April 15, 2013
Clindamycin phosphate scavenges hydroxyl radical
Emiko Sato1, Masatoshi Kato, Masahiro Kohno
1New Industry Creation Hatchery Center, Tohoku University, Sendai, Japan.
International Journal of Dermatology
|November 9, 2007
Summary
Clindamycin phosphate (CLDMP) directly scavenges hydroxyl radicals, demonstrating potent anti-inflammatory properties. This finding suggests CLDMP may help mitigate inflammation caused by bacterial infections.
Area of Science:
- Pharmacology
- Biochemistry
- Inflammation Research
Background:
- Clindamycin phosphate (CLDMP) exhibits efficacy against Gram-positive and anaerobic bacteria.
- CLDMP possesses known anti-inflammatory characteristics.
Purpose of the Study:
- To investigate the anti-inflammatory mechanisms of CLDMP.
- To evaluate the radical scavenging activity of CLDMP.
Main Methods:
- Electron spin resonance (ESR) spin trapping technique was employed.
- Scavenging effects on superoxide anion and hydroxyl radical were assessed.
Main Results:
- CLDMP did not scavenge superoxide anion in a hypoxanthine-xanthine oxidase system.
- CLDMP demonstrated direct and potent scavenging of hydroxyl radical in a Fenton reaction system, exceeding mannitol's activity.
- The scavenging activity was confirmed by changes in IC(50) with a spin trapping agent.
Conclusions:
- This study provides the first evidence of CLDMP's direct hydroxyl radical scavenging effect.
- This direct scavenging action of CLDMP may contribute to improved inflammatory responses in bacterial infections.
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