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Creatine monohydrate in resistant depression: a preliminary study.

Suzana Roitman1, Tamar Green, Yamima Osher

  • 1Ness Ziona Mental Health Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Bipolar Disorders
|November 9, 2007
PubMed
Summary
This summary is machine-generated.

Creatine supplementation may improve unipolar depression symptoms but carries a risk of inducing mania in bipolar depression patients. Further research is needed for this brain energy supplement.

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Area of Science:

  • Neuroscience
  • Biochemistry
  • Psychiatry

Background:

  • Altered brain energy metabolism is implicated in depression.
  • Creatine is vital for brain energy homeostasis.

Purpose of the Study:

  • To investigate the effects of oral creatine monohydrate supplementation in patients with treatment-resistant depression.
  • To assess creatine's impact on mood and anxiety symptoms.

Main Methods:

  • An open-label, add-on study involving 10 patients (8 unipolar, 2 bipolar) with treatment-resistant depression.
  • Patients received 3-5 g/day of creatine monohydrate for four weeks.
  • Standardized depression and anxiety scales were used for outcome assessment.

Main Results:

  • Significant improvements were observed in depression, anxiety, and global impression scores for seven unipolar patients.
  • One patient with unipolar depression showed rapid improvement and withdrew.
  • Both bipolar patients experienced hypomania or mania, indicating a potential risk of manic switch.

Conclusions:

  • Creatine monohydrate shows promise as an adjunctive treatment for unipolar depression.
  • Caution is advised due to the risk of precipitating manic episodes in bipolar depression patients.