Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Dysbiosis of the Gut Microbiota01:18

Dysbiosis of the Gut Microbiota

The human gut microbiome includes a diverse array of microbial species, including beneficial commensals and opportunistic pathogens, which interact to support host health. These microbes contribute to essential functions such as nutrient metabolism, immune system modulation, and maintenance of intestinal barrier integrity. However, disruptions to this equilibrium—referred to as dysbiosis—can have widespread physiological consequences.Dysbiosis is often characterized by reduced microbial...
Microbiota of the Stomach and Small Intestine01:27

Microbiota of the Stomach and Small Intestine

The human gastrointestinal (GI) tract is characterized by distinct physicochemical conditions that shape its microbial communities. Among these, the stomach presents a particularly challenging environment for microbial colonization due to its highly acidic pH, ranging from 1 to 3. This extreme acidity effectively limits microbial density. However, certain acid-tolerant microorganisms are capable of surviving in this niche. Notably, Helicobacter pylori can colonize the gastric mucosa,...
Microbiota of the Large Intestine01:27

Microbiota of the Large Intestine

The large intestine hosts the most densely populated microbial ecosystem in the human body. This complex community primarily consists of anaerobic bacteria, with Bacillota (formerly Firmicutes) and Bacteroidota (formerly Bacteroidetes) as the predominant groups. The distribution of these microbes varies along different sections of the large intestine, influenced by local environmental factors such as oxygen availability and nutrient composition.The cecum, located at the beginning of the large...
Development of Human Microbiota01:30

Development of Human Microbiota

The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from the skin...
Bacterial Flora of the Large Intestine01:29

Bacterial Flora of the Large Intestine

The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
Functions of the Gut Microbiota01:18

Functions of the Gut Microbiota

The gut microbiota includes trillions of microorganisms that colonize the human gastrointestinal tract, including bacteria, archaea, viruses, and fungi. This complex ecosystem plays a critical role in maintaining intestinal and systemic health. Most of these microbes inhabit the large intestine, establishing a relatively stable and diverse community that contributes to gut homeostasis through various metabolic, immunological, and protective mechanisms.Dominant bacterial phyla, such as...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Factors related to loss to follow-up and low compliance in Helicobacter pylori-infected children: The EuroPedHp Registry.

Journal of pediatric gastroenterology and nutrition·2026
Same author

1-(1-naphthylmethyl)-piperazine Inhibition assay successfully rules out efflux pump overexpression in Acinetobacter baumannii.

Molecular biology reports·2025
Same author

Plasmid Dissemination in Multispecies Carbapenemase-Producing Enterobacterales Outbreaks Involving Clinical and Environmental Strains: A Narrative Review.

Microorganisms·2025
Same author

Food protein induced enterocolitis syndrome: French practices assessment in children.

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie·2025
Same author

Growth, Safety and Tolerance in Infants Fed Rice Protein Hydrolysate Formula: The GRITO Randomised Controlled Trial.

Nutrients·2025
Same author

Factors Associated With Decision to Treat or Not to Treat Helicobacter pylori Infection in Children: Data From the EuroPedHp Registry.

Helicobacter·2024

Related Experiment Video

Updated: Jul 10, 2026

Assessment of Intestinal Transcytosis of Neonatal Escherichia coli Bacteremia Isolates
08:32

Assessment of Intestinal Transcytosis of Neonatal Escherichia coli Bacteremia Isolates

Published on: February 17, 2023

Does the intestinal bifidobacterial colonisation affect bacterial translocation?

Marie-Bénédicte Romond1, Michel Colavizza, Catherine Mullié

  • 1Laboratoire de Microbiologie, Faculté des Sciences Pharmaceutiques et Biologiques, 3 rue du Pr. Laguesse, B.P. 83, 59006 Lille Cedex, France. marie-benedicte.romond@univ-lille2.fr

Anaerobe
|November 9, 2007
PubMed
Summary

High levels of bifidobacteria in the gut limit bacterial translocation (BT) to internal organs, reducing sepsis risk. Conversely, Bacteroides fragilis and clostridia promote BT, suggesting targeted flora modulation for health.

More Related Videos

Injections of Lipopolysaccharide into Mice to Mimic Entrance of Microbial-derived Products After Intestinal Barrier Breach
08:24

Injections of Lipopolysaccharide into Mice to Mimic Entrance of Microbial-derived Products After Intestinal Barrier Breach

Published on: May 2, 2018

Related Experiment Videos

Last Updated: Jul 10, 2026

Assessment of Intestinal Transcytosis of Neonatal Escherichia coli Bacteremia Isolates
08:32

Assessment of Intestinal Transcytosis of Neonatal Escherichia coli Bacteremia Isolates

Published on: February 17, 2023

Injections of Lipopolysaccharide into Mice to Mimic Entrance of Microbial-derived Products After Intestinal Barrier Breach
08:24

Injections of Lipopolysaccharide into Mice to Mimic Entrance of Microbial-derived Products After Intestinal Barrier Breach

Published on: May 2, 2018

Area of Science:

  • Microbiology
  • Gastroenterology
  • Immunology

Background:

  • Bacterial translocation (BT) facilitates sepsis in conditions like pancreatitis and cirrhosis.
  • Intestinal anaerobic flora plays a role in regulating BT.
  • Understanding specific bacterial groups' impact on BT is crucial for disease management.

Purpose of the Study:

  • To investigate the role of intestinal anaerobic flora, particularly bifidobacteria, in regulating bacterial translocation (BT).
  • To determine the correlation between specific bacterial populations and the extent of BT.
  • To identify bacterial targets for modulating BT.

Main Methods:

  • Human flora-associated mice (HF mice) were used to study intestinal flora.
  • Bacterial translocation (BT) was quantified in Peyer's patches (PP), blood, spleen, liver, and lungs.
  • Correlations between bifidobacteria, Bacteroides fragilis group, clostridia, and BT were analyzed.

Main Results:

  • High bifidobacteria colonization in the cecum and colon correlated with reduced bacterial contamination in blood, liver, and lungs.
  • Bifidobacterial counts negatively correlated with bacterial dissemination across organs.
  • Bacteroides fragilis group counts positively correlated with bacteremia and dissemination, while clostridia in the colon promoted BT to the lungs.

Conclusions:

  • Bifidobacteria, at high densities, reduce BT to vital organs, thus mitigating sepsis risk.
  • Bacteroides fragilis group and certain clostridia promote BT, indicating potential pathogenic roles.
  • Selective promotion of bifidobacteria and suppression of detrimental bacteria could be a therapeutic strategy for managing BT.