[Pathophysiologic changes in induced micro- and macroembolisms in the lungs in an animal experiment]

The investigation deals with experimentally induced micro- and macro-embolization of the lungs in experiments on rabbits. The main changes occurred at the investigated pressures in the right ventricle and a. fem. sin., in the respiration rate and blood gases. A considerable rise of the systolic pressure in the right ventricle and the corresponding drop of the systemic pressure in animals with macroembolization of the lungs is followed not only by an increase of the respiration rate but above all by a shift of the pH to the acid side. The other components of blood gases suggest rather the development of metabolic acidosis. The latter is also indicated in microembolization of the lungs, there, however, the pressure changes are not so marked and there is only an increased respiration rate.