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Psoriasis and the metabolic syndrome
Arnon D Cohen1, Harel Gilutz, Yaakov Henkin
1Clalit Health Services, Ben-Gurion University, Beer-Sheva, Isreal. arcohen@clalit.org.il
Acta Dermato-Venereologica
|November 9, 2007
Summary
This study found that psoriasis is associated with an increased risk of metabolic syndrome, including conditions like obesity, hypertension, and diabetes. These findings highlight the importance of considering metabolic health in psoriasis patients.
Area of Science:
- Dermatology
- Cardiology
- Endocrinology
Background:
- Psoriasis vulgaris has been linked to metabolic conditions, but previous studies lacked robust controls and sufficient sample sizes.
- The metabolic syndrome, a cluster of conditions increasing cardiovascular risk, warrants further investigation in relation to psoriasis.
Purpose of the Study:
- To investigate the association between psoriasis vulgaris and the metabolic syndrome using a case-control study design.
- To compare the prevalence of metabolic syndrome components in psoriasis patients versus a control group.
Main Methods:
- A case-control study utilizing data mining from Clalit Health Services database.
- Case patients diagnosed with psoriasis vulgaris; control patients underwent hernioplasty or appendectomy.
- Univariate analyses and logistic regression models were employed to assess associations, adjusting for age and gender.
Main Results:
- Psoriasis patients showed significantly higher rates of ischaemic heart disease, diabetes mellitus, hypertension, obesity, and dyslipidaemia compared to controls.
- The association was more pronounced in men and individuals over 50 years of age.
- Psoriasis was linked to increased odds of ischaemic heart disease (OR 1.4), diabetes (OR 1.5), hypertension (OR 1.3), obesity (OR 1.3), and dyslipidaemia (OR 1.2).
Conclusions:
- Psoriasis vulgaris is associated with an increased prevalence of metabolic syndrome components.
- The findings suggest a significant link between psoriasis and metabolic dysfunction, particularly in men and older adults.
- Further research is recommended to confirm these associations and explore underlying mechanisms.
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