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A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
Distal embolic protection for renal arterial interventions
Gregory J Dubel1, Timothy P Murphy
1Department of Diagnostic Imaging, Division of Interventional Radiology, Brown University Medical School, Providence, RI 02903, USA. gdubel@lifespan.org
Cardiovascular and Interventional Radiology
|November 9, 2007
Summary
Distal protection devices (DPDs) can capture embolic material during renal artery interventions, potentially preventing kidney damage. Early studies show DPDs improve or stabilize renal function in most patients, highlighting their benefit.
Area of Science:
- Interventional Cardiology
- Nephrology
- Vascular Surgery
Background:
- Embolization of plaque debris during renal artery interventions can lead to kidney damage.
- Distal protection devices (DPDs) are used in other vascular beds to capture embolic material.
- Renal artery stenosis is common in patients with chronic kidney disease.
Purpose of the Study:
- To evaluate the efficacy of DPDs in preventing distal embolization during renal artery interventions.
- To assess the impact of DPDs on renal function preservation in patients undergoing renal artery stenting.
Main Methods:
- Review of literature on DPD use in renal artery interventions.
- Analysis of early clinical experience with DPDs in the renal vasculature.
- Assessment of embolic material retrieval and renal function outcomes.
Main Results:
- Atheroembolization occurs during renal interventions, often undetected.
- DPDs retrieved embolic materials in approximately 71% of cases.
- Renal function was improved or stabilized in 98% of patients treated with DPDs.
Conclusions:
- DPDs appear beneficial in limiting distal embolization during renal artery interventions.
- The use of DPDs, when anatomically feasible, is recommended for renal functional preservation.
- Combining DPDs with platelet inhibition may offer additional benefits.
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