Carboxymethyl cellulose (CMC) based semi-IPNs as carriers for controlled release of ciprofloxacine: an in-vitro...

Semi-interpenetrating polymer networks (IPNs) of carboxymethyl cellulose (CMC) and polyacrylic acid were prepared and its potential for controlled release of ciprofloxacine (Cfx) was assessed. The IPNs were characterized by IR spectral analysis and Environmental scanning electron microscopy (ESEM). The entrapped drug was examined for its antibacterial activity and chemical stability. The effects of experimental parameters such as varying chemical composition of the IPNs, percent loading of Cfx, pH and temperature of release medium and presence of salt ions in outer solution were examined on the release profile of the drug. On the basis of Fick's power law equations, the diffusion exponents (n) and diffusion constant (D) were evaluated for different IPNs compositions. From the kinetic parameter data, an attempt was made to resolve the mechanism of the release process of Cfx.