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Related Experiment Videos

IGF-I and IGFBP-3 during continuous and interval exercise.

J L Copeland1, L Heggie

  • 1Department of Kinesiology, University of Lethbridge, Lethbridge, Canada. jennifer.copeland@uleth.ca

International Journal of Sports Medicine
|November 9, 2007
PubMed
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Both continuous and interval exercise increase Insulin-like Growth Factor (IGF-I) and IGF Binding Protein 3 (IGFBP-3). Interval training may yield a greater IGFBP-3 response than continuous exercise.

Area of Science:

  • Exercise Physiology
  • Endocrinology
  • Sports Science

Background:

  • Circulating Insulin-like Growth Factor-I (IGF-I) and IGF Binding Protein 3 (IGFBP-3) play crucial roles in cellular processes.
  • Understanding how different exercise intensities affect these factors is important for exercise prescription and health.
  • Previous research has explored exercise-induced changes in IGF-I and IGFBP-3, but direct comparisons between continuous and interval training protocols are less common.

Purpose of the Study:

  • To compare the changes in circulating total IGF-I and IGFBP-3 levels between continuous, moderate-intensity exercise (CE) and high-intensity interval exercise (IE) of equal duration.
  • To investigate the acute effects of different exercise modalities on key growth factors.

Main Methods:

  • Ten healthy males participated in a randomized crossover study involving two exercise sessions (CE and IE) and a resting control session (R).

Related Experiment Videos

  • CE involved 20 minutes of cycling at 60-65% of V̇O2max.
  • IE consisted of 20 minutes of cycling alternating 1-minute intervals at 80-85% of V̇O2max with 40-second active recovery periods.
  • Blood samples were collected at multiple time points before, during, and after each session.

    • Main Results:

    • Both IGF-I and IGFBP-3 levels increased significantly during both CE and IE compared to rest (p < 0.05).
    • Repeated measures ANOVA indicated a significant effect for exercise session, with both IE and CE showing greater responses than rest (p < 0.05).
    • Area under the curve (AUC) analysis revealed no significant difference in IGF-I response between CE and IE, but the IGFBP-3 AUC was significantly higher during IE compared to rest (p < 0.05).

    Conclusions:

    • Continuous and high-intensity interval exercise elicit similar acute changes in circulating IGF-I.
    • High-intensity interval exercise may lead to a greater increase in circulating IGFBP-3 compared to a resting state.
    • These findings suggest that both exercise types can influence IGF-I and IGFBP-3, with potential benefits for individuals who prefer or can sustain higher intensities through intervals.