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Nondisjunction01:21

Nondisjunction

Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate correctly and move to the opposite poles of the cells. This produces daughter cells with abnormal chromosome numbers.  Nondisjunction is common during anaphase I or anaphase II of meiosis.  Mutations in synaptonemal complex proteins that attach homologous chromosomes increase the chances of nondisjunction in anaphase I of meiosis I. In contrast, mutations in topoisomerases and condensins that hold sister...
Nondisjunction01:29

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During meiosis, chromosomes occasionally separate improperly. This occurs due to failure of homologous chromosome separation during meiosis I or failed sister chromatid separation during meiosis II. In some species, notably plants, nondisjunction can result in an organism with an entire additional set of chromosomes, which is called polyploidy. In humans, nondisjunction can occur during male or female gametogenesis and the resulting gametes possess one too many or one too few chromosomes.
Nondisjunction01:29

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The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...

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Birth defects interstate data exchange: a battle worth fighting?

Cynthia Cassell1, Cara Mai, Russel Rickard

  • 1North Carolina Birth Defects Monitoring Program, State Center for Health Statistics, Division of Public Health, Raleigh, North Carolina, USA. cynthia.cassell@ncmail.net

Birth Defects Research. Part A, Clinical and Molecular Teratology
|November 9, 2007
PubMed
Summary
This summary is machine-generated.

Few states have interstate birth defects data exchange agreements, impacting surveillance. Establishing these agreements, even with neighboring states, can significantly improve birth defect monitoring nationwide.

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Area of Science:

  • Public Health
  • Epidemiology
  • Biostatistics

Background:

  • Effective birth defect surveillance requires including all children within a defined catchment area.
  • Limited understanding exists regarding the impact of lacking interstate data exchange on birth defect surveillance programs.

Purpose of the Study:

  • To assess the current status of interstate birth defect data exchange agreements.
  • To quantify the extent of resident births occurring in non-resident states.

Main Methods:

  • Surveys were distributed to U.S. population-based birth defect programs to identify existing data exchange agreements, barriers, and the impact of out-of-state births.
  • National Center for Health Statistics (NCHS) data from 2002 on live birth residency were analyzed to determine out-of-state birth frequencies.

Main Results:

  • Only 21% of responding states had existing interstate data exchange agreements for birth defect data.
  • 53% of responding states planned to develop such agreements.
  • Actual percentages of resident out-of-state live births ranged from 0.16% to 11.51%, with potential for significant capture improvement through neighboring state data sharing.

Conclusions:

  • Interstate birth defect data exchange agreements are uncommon, despite all states having resident births occurring out-of-state.
  • Further data are needed to fully quantify the impact on state-based birth defect programs.
  • Establishing agreements with key neighboring states offers a practical approach to enhance national birth defect surveillance.