Related Experiment Video
Updated: Jul 10, 2026

High Sensitivity Measurement of Transcription Factor-DNA Binding Affinities by Competitive Titration Using Fluorescence Microscopy
Published on: February 7, 2019
Discovering motifs with transcription factor domain knowledge
Henry C M Leung1, Francis Y L Chin, Bethany M Y Chan
1Department of Computer Science, University of Hong Kong, Pokfulam, Hong Kong, China.
Abstract:
We introduce a new motif-discovery algorithm, DIMDom, which exploits two additional kinds of information not commonly exploited: (a) the characteristic pattern of binding site classes, where class is determined based on biological information about transcription factor domains and (b) posterior probabilities of these classes. We compared the performance of DIMDom with MEME on all the transcription factors of Drosophila with at least one known binding site in the TRANSFAC database and found that DOMDom outperformed MEME with 2.5 times the number of successes and 1.5 times in the accuracy in finding binding sties and motifs.
Related Concept Videos
Transcription Factors
Transcription Factors
General Transcription Factors
Eukaryotic Transcription Activators
The binding domains are capable of recognizing and interacting with regulatory sequences on the DNA. These domains are...
Conserved Binding Sites
Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally analyses the...
Cooperative Binding of Transcription Regulators

