Related Experiment Video

Updated: Jul 10, 2026

Laparoscopy-endoscopy Cooperative Surgery for the Treatment of Gastric Gastrointestinal Stromal Tumors
05:16

Laparoscopy-endoscopy Cooperative Surgery for the Treatment of Gastric Gastrointestinal Stromal Tumors

Published on: February 19, 2022

Gastric GISTs. Personal experience

Giuseppe Pietro Mingolla1, Paolo Antonino Riccio, Romano Linguerri

  • 1Unità Operativa di Chirurgia Generale, AUSL Imola, Imola, Italy. pieromingolla@libero.it

Annali Italiani Di Chirurgia
|November 10, 2007
PubMed
Abstract

Insights

Gastrointestinal stromal tumors (GISTs) are rare mesenchymal neoplasms. Surgical resection is key for localized GISTs, while Imatinib Mesylate shows promise for metastatic disease.

Area of Science:

  • Gastroenterology and Surgical Oncology
  • Molecular Targeted Therapy

Background:

  • Gastrointestinal stromal tumors (GISTs) are defined by CD117 immunopositivity.
  • Surgery is the primary treatment for GISTs.
  • Imatinib Mesylate is effective for unresectable or metastatic GISTs.

Observation:

  • This study reviewed 12 gastric mesenchymal neoplasms, identifying 8 GISTs (67%) via CD117.
  • The median follow-up was 37 months.
  • A case of metastatic GIST treated with Imatinib Mesylate for 15 months is detailed.

Findings:

  • Gastrointestinal bleeding was the most common symptom.
  • Malignant GISTs >5cm or with high mitotic counts require careful management.
  • Complete surgical resection with clear margins prevented recurrence in localized GISTs.
  • Imatinib Mesylate demonstrated a positive response in a metastatic GIST case.

Implications:

  • Complete surgical resection remains crucial for gastric GISTs.
  • Surgical intervention is advised for advanced GISTs, even with metastases, to facilitate palliative Imatinib Mesylate treatment.
  • Imatinib Mesylate can stabilize or induce partial remission in advanced GIST patients.

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