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Appendicitis-I: Introduction

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Utilizing the Antigen Capsid-Incorporation Strategy for the Development of Adenovirus Serotype 5-Vectored Vaccine Approaches

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Published on: May 6, 2015

Adenoviral appendicitis presenting clinically as acute appendicitis.

David Grynspan¹, Raja Rabah

¹Department of Pathology, Children's Hospital of Michigan and Wayne State University, 3901 Beaubien Street, Detroit, MI 48201-2119, USA.

Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society

|November 10, 2007

Summary

Adenovirus can cause appendicitis, mimicking the condition without intussusception. This study found adenoviral infection in negative appendectomies, suggesting a role in acute appendicitis pathogenesis.

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Area of Science:

Virology
Gastroenterology
Pathology

Background:

Appendiceal viral infections are rarely documented histologically.
Adenovirus is linked to mesenteric adenitis and intussusception, but not typically acute appendicitis without these conditions.

Observation:

A retrospective review of 877 appendectomies (2001-2005) identified 94 pathologically negative cases with clinical acute appendicitis.
Sixty-three of these negative cases showed lymphoid hyperplasia and were tested for adenovirus.

Findings:

Two cases (a 6-year-old male and a 5-year-old female) tested positive for adenovirus.
These positive cases exhibited epithelial proliferation and viral inclusions, without intussusception.

Implications:

Adenovirus infection can clinically present as acute appendicitis, even without intussusception.
Histological evaluation of negative appendectomies for viral changes, including adenovirus, is recommended.
Adenovirus may contribute to the development of acute appendicitis.