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Updated: Jul 10, 2026
08:01
Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology
Published on: March 22, 2012
Invasive sinus aspergillosis with perineural spread in an immunocompetent patient
S Subramanian1, H Kandpal, R Sharma
1Radiodiagnosis, AIIMS, New Delhi, India.
Australasian Radiology
|December 6, 2007
Summary
Invasive aspergillosis, a fungal infection, rarely affects immunocompetent individuals. This case highlights a unique instance of paranasal sinus and orbital aspergillosis with intracranial spread in a healthy patient.
Area of Science:
- Mycology
- Neurology
- Ophthalmology
Background:
- Invasive aspergillosis typically affects immunocompromised individuals, carrying a high mortality rate.
- Paranasal sinus aspergillosis is a serious condition, rarely observed in immunocompetent hosts.
Observation:
- A rare case of invasive aspergillosis involving the paranasal sinus and orbit is detailed.
- The infection extended intracranially through perineural spread along the maxillary division of the trigeminal nerve.
Findings:
- Demonstrates an unusual presentation of invasive fungal sinusitis in an immunocompetent patient.
- Highlights the potential for perineural spread of Aspergillus in the absence of immunosuppression.
Implications:
- Suggests that invasive aspergillosis should be considered in immunocompetent patients with complex sinonasal and orbital infections.
- Underscores the importance of recognizing rare routes of intracranial extension, such as perineural spread.
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