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Related Concept Videos

Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Genital Herpes01:23

Genital Herpes

Genital herpes is a sexually transmitted infection primarily caused by herpes simplex virus type 2 (HSV-2), though herpes simplex virus type 1 (HSV-1) is increasingly implicated in genital infections, particularly among younger populations. Transmission occurs mainly through sexual contact, with asymptomatic viral shedding serving as a major route of spread. This characteristic makes HSV-2 difficult to control at a population level, as individuals may unknowingly transmit the virus even in the...
Herpes01:28

Herpes

Herpes simplex type 1 (HSV‑1) is a widespread pathogen responsible for orolabial lesions. It is an enveloped, double-stranded DNA (dsDNA) virus belonging to the family Herpesviridae. Once the virus infects a host cell, its double‑stranded DNA genome is delivered into the nucleus, where a coordinated cascade of immediate‑early, early, and late gene expression directs viral DNA replication, structural protein synthesis, and virion assembly. After primary infection of epithelial cells, HSV-1...

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Updated: Jul 10, 2026

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)
07:02

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)

Published on: September 14, 2010

KSHV/HHV8-associated lymphomas.

Antonino Carbone1, Annunziata Gloghini

  • 1Department of Pathology, Istituto Nazionale Tumori, Milan, Italy. antonino.carbone@istitutotumori.mi.it

British Journal of Haematology
|November 10, 2007
PubMed
Summary
This summary is machine-generated.

Primary effusion lymphoma (PEL) and Kaposi sarcoma herpesvirus (KSHV)/human herpesvirus 8 (HHV8)-associated lymphomas share characteristics despite varied presentations. Research explores novel therapies beyond traditional chemotherapy for these aggressive KSHV/HHV8-associated malignancies.

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Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)
07:02

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)

Published on: September 14, 2010

Quantitative Fluorescence In Situ Hybridization (FISH) and Immunofluorescence (IF) of Specific Gene Products in KSHV-Infected Cells
06:21

Quantitative Fluorescence In Situ Hybridization (FISH) and Immunofluorescence (IF) of Specific Gene Products in KSHV-Infected Cells

Published on: August 27, 2019

Area of Science:

  • Oncology
  • Virology
  • Hematology

Background:

  • Primary effusion lymphoma (PEL) and Kaposi sarcoma herpesvirus (KSHV)/human herpesvirus 8 (HHV8)-associated lymphomas represent a distinct group of non-Hodgkin lymphomas.
  • KSHV/HHV8 DNA was first identified in AIDS-related lymphomas within body cavities in 1995.
  • The spectrum has expanded to include extracavitary solid lymphomas, though many share similar morphology, immunophenotype, and viral status.

Purpose of the Study:

  • To review the current knowledge on KSHV/HHV8-associated lymphomas, including PEL.
  • To discuss the clinical presentation, pathological features, and oncogenic mechanisms.
  • To explore novel therapeutic strategies for these challenging hematologic malignancies.

Main Methods:

  • Literature review of primary effusion lymphoma and KSHV/HHV8-associated lymphomas.
  • Analysis of clinical presentations, morphology, immunophenotype, and viral status.
  • Examination of proposed therapeutic approaches beyond conventional chemotherapy.

Main Results:

  • KSHV/HHV8-associated lymphomas, including PEL, exhibit diverse clinical presentations but often share core pathological features.
  • KSHV/HHV8 infection is also implicated in multicentric Castleman disease-associated plasmablastic lymphoma.
  • The precise oncogenic mechanisms of KSHV/HHV8 remain incompletely understood, and the prognosis is generally poor.

Conclusions:

  • Despite clinical diversity, KSHV/HHV8-associated lymphomas present a consistent clinicopathologic entity.
  • Novel therapeutic strategies, including antiviral therapy and targeted agents, are being investigated to improve outcomes.
  • Further research into KSHV/HHV8 oncogenesis is crucial for developing more effective treatments.