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Post-infectious irritable bowel syndrome.

Andrew W Dupont¹

¹Division of Gastroenterology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-0764, USA. awdupont@utmb.edu

Current Gastroenterology Reports

|November 10, 2007

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Post-infectious irritable bowel syndrome (PI-IBS) can develop after acute gastroenteritis, persisting with abdominal discomfort and altered bowel habits. While inflammation plays a role, PI-IBS patients show a slightly better prognosis than other IBS cases.

Area of Science:

Gastroenterology
Immunology
Microbiology

Background:

Irritable bowel syndrome (IBS) is a prevalent functional gastrointestinal disorder.
A subset of IBS cases, termed post-infectious IBS (PI-IBS), originate after acute gastroenteritis.
PI-IBS symptoms include persistent abdominal discomfort, bloating, and altered bowel habits post-infection.

Purpose of the Study:

To investigate the characteristics and potential mechanisms of post-infectious IBS (PI-IBS).
To compare PI-IBS with general IBS regarding pathophysiology and prognosis.

Main Methods:

Review of existing literature on PI-IBS onset, pathophysiology, and clinical features.
Analysis of proposed mechanisms including inflammation, cellular changes, and gut permeability.

Related Experiment Videos

Comparison of PI-IBS patient data with general IBS cohorts.

Main Results:

PI-IBS is characterized by persistent gastrointestinal symptoms following acute gastroenteritis.
Underlying mechanisms may involve increased inflammation, enterochromaffin cells, lymphocytes, mast cells, cytokines, and intestinal permeability.
Psychiatric comorbidities are less frequent in PI-IBS than in general IBS but still elevated compared to the general population.

Conclusions:

Post-infectious IBS involves specific pathophysiological changes driven by inflammation.
While PI-IBS shares features with general IBS, it presents a slightly improved prognosis.
Further research is needed to fully elucidate PI-IBS mechanisms and optimize patient outcomes.