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Updated: Jul 10, 2026
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Murine Model for Non-invasive Imaging to Detect and Monitor Ovarian Cancer Recurrence
Published on: November 2, 2014
Contemporary progress in ovarian cancer screening
Christine S Walsh1, B Y Karlan
1Department of Obstetrics and Gynecology, University of California, Los Angeles, David Geffen School of Medicine at UCLA, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Suite 160W, Los Angeles, CA 90048, USA. walshc@cshs.org
Current Oncology Reports
|November 10, 2007
Summary
Early detection of ovarian cancer is difficult due to limited biological understanding and low prevalence. Current screening tests do not meet the high specificity and mortality reduction standards required for effective population-level screening programs.
Area of Science:
- Gynecologic Oncology
- Cancer Screening
- Public Health
Background:
- Ovarian cancer presents diagnostic challenges due to its complex biology and low incidence.
- Effective population-level screening requires demonstrated mortality benefit and high specificity.
Purpose of the Study:
- To review the current state of ovarian cancer screening.
- To identify challenges in developing effective screening strategies.
Main Methods:
- Literature review of existing ovarian cancer screening studies.
- Analysis of evidence-based principles for cancer screening programs.
Main Results:
- No current ovarian cancer screening tests meet the criteria for beneficial population-level screening.
- High specificity is crucial to avoid harms from false-positive results.
Conclusions:
- Developing a successful ovarian cancer screening test remains a significant challenge.
- Future screening efforts must prioritize mortality reduction and minimize false positives.
