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Primary neuroectodermal tumor of penis (PNET)--a case report
Dipak Paruliya1, Shaleen Sharma, Sunil Gokhroo
1Department of Urology, Sawai Man Singh Medical College, Jaipur, Rajasthan, India. dipakparuliya@yahoo.com
Urology
|November 10, 2007
Summary
A rare and aggressive primary neuroectodermal tumor (PNET) was diagnosed in a teenage male with penile nodules. Treatment involved surgery and chemotherapy for this uncommon extraskeletal PNET presentation.
Area of Science:
- Oncology
- Pathology
- Urology
Background:
- Primary neuroectodermal tumors (PNETs) are rare, highly malignant neoplasms with a predilection for skeletal involvement.
- Extraskeletal PNETs are uncommon, and PNET of the penis is exceptionally rare, with limited case reports in medical literature.
Observation:
- A 17-year-old male presented with a four-week history of painless penile swelling.
- Physical examination identified multiple, 1 cm hard nodules on the penile shaft.
- An incisional biopsy revealed an undifferentiated malignant round cell tumor, diagnosed as PNET via immunohistochemistry.
Findings:
- The penile tumor was confirmed as a primary neuroectodermal tumor (PNET).
- Metastatic workup was negative, indicating a localized disease at presentation.
- The patient underwent total penectomy and perineal urethrostomy, followed by adjuvant chemotherapy.
Implications:
- This case highlights the possibility of extraskeletal PNET in the penis, emphasizing the need for considering rare diagnoses in genitourinary oncology.
- Early diagnosis and aggressive multimodal treatment, including surgery and chemotherapy, are crucial for managing this rare penile malignancy.
- Further research into the specific characteristics and optimal management of penile PNETs is warranted due to their extreme rarity.
