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MEROPS: the peptidase database.

Neil D Rawlings1, Fraser R Morton, Chai Yin Kok

  • 1The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK. ndr@sanger.ac.uk

Nucleic Acids Research
|November 10, 2007
PubMed
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The MEROPS database provides integrated information on peptidases (proteolytic enzymes or proteases), their substrates, and inhibitors. It features hierarchical classification and new tools for comparing enzyme complements across organisms.

Area of Science:

  • Biochemistry
  • Bioinformatics
  • Molecular Biology

Background:

  • Peptidases (proteolytic enzymes or proteases), their substrates, and inhibitors are crucial in biological processes, medicine, and biotechnology.
  • An integrated information source is needed for these key biomolecules.

Purpose of the Study:

  • To present the MEROPS database as a comprehensive resource for peptidase and inhibitor information.
  • To detail recent updates and new functionalities enhancing the database's utility.

Main Methods:

  • Hierarchical classification of peptidases and protein inhibitors into species, families, and clans.
  • Compilation of text annotations, substrate specificities, and inhibitor interactions.
  • Development of comparative genomic tools for peptidase and inhibitor analysis.

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Main Results:

  • MEROPS database offers a structured classification of peptidases and inhibitors.
  • Includes new annotations for clans, small molecule inhibitors, substrate specificities, and peptidase-inhibitor interactions.
  • Provides dynamic alignments and comparative genomic analysis tools.

Conclusions:

  • The MEROPS database serves as an essential integrated resource for peptidases and inhibitors.
  • Recent enhancements facilitate deeper understanding and comparative analysis of these vital biomolecules across species.