Related Experiment Video
Updated: Jul 10, 2026
08:26
Design of a Biocompatible Drug-Eluting Tracheal Stent in Mice with Laryngotracheal Stenosis
Published on: January 21, 2020
Does the use of paclitaxel or rapamycin-eluting stent decrease further need for coronary-artery bypass grafting when
Hernani Pinto de Lemos1, Alvaro Nagib Atallah
1Brazilian Cochrane Center, Universidade Federal de São Paulo-Escola Paulista de Medicina, São Paulo, Brazil. cochrane.dmed@epm.br
Sao Paulo Medical Journal = Revista Paulista De Medicina
|November 10, 2007
Summary
Drug-eluting stents, used to prevent coronary-artery bypass grafting, showed no significant difference compared to bare-metal stents. The study found no reduction in surgical revascularization rates with drug-eluting stent use.
Area of Science:
- Cardiovascular Medicine
- Interventional Cardiology
Background:
- Drug-eluting stents (DES) are designed to reduce restenosis and the need for repeat procedures.
- Surgical revascularization, such as coronary-artery bypass grafting (CABG), is a major treatment for coronary artery disease.
Purpose of the Study:
- To evaluate the effectiveness of paclitaxel or rapamycin-eluting stents in preventing the need for coronary-artery bypass grafting (CABG).
Main Methods:
- Systematic review of the literature adhering to Cochrane Collaboration methodology.
- Inclusion of controlled randomized trials comparing drug-eluting stents (DES) or bare-metal stents (BMS).
- Primary outcome assessed was the rate of coronary-artery bypass grafting (CABG).
Main Results:
- Ten studies were included in the systematic review.
- No statistically significant difference was observed between DES and BMS regarding the need for CABG (Confidence Interval: 0.31 to 1.42).
Conclusions:
- The use of drug-eluting stents did not demonstrate a reduction in the rate of surgical revascularization.
- Current evidence does not support a significant benefit of DES over BMS in preventing CABG.
Related Concept Videos
01:27Peripheral Artery Disease III: Interprofessional Care
Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
01:27Coronary Artery Disease V: Interprofessional Care
Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...