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Anti-SSB/La antibody is negatively associated with HLA-DR2 in chronic hepatitis C infection

Chien-Sheng Wu1, Chung-Yi Hu, Ping-Ning Hsu

  • 1Division of Rheumatology, Department of Internal Medicine, Far Eastern Memorial Hospital, Taipei, Taiwan, Republic of China.

Clinical Rheumatology
|November 10, 2007
PubMed

Insights

Hepatitis C virus (HCV) infection frequently involves anti-SSA/Ro and anti-SSB/La autoantibodies. This study found anti-SSB/La antibodies negatively correlate with HLA-DR2 in Taiwanese HCV patients.

Area of Science:

  • Immunology
  • Hepatology
  • Genetics

Background:

  • Hepatitis C virus (HCV) infection is often linked to specific autoantibodies.
  • Understanding these associations may offer insights into HCV pathogenesis and patient subsets.

Purpose of the Study:

  • To determine the prevalence of anti-SSA/Ro and anti-SSB/La autoantibodies in HCV patients.
  • To investigate the association between these autoantibodies and HLA-DRB1 polymorphism in Taiwanese Chinese patients.

Main Methods:

  • Recruited 288 HCV-infected patients for autoantibody detection and HLA-DRB1 typing.
  • Utilized serological assays for autoantibody detection.
  • Employed HLA typing techniques for genetic analysis.

Main Results:

  • Prevalence rates for anti-SSA/Ro and anti-SSB/La antibodies were 12.8% and 9.7%, respectively.
  • Anti-SSA/Ro antibodies showed a positive association with age over 55 (p=0.04).
  • Anti-SSB/La antibodies demonstrated a negative association with HLA-DR2 carriage (p=0.024).

Conclusions:

  • Anti-SSA/Ro and anti-SSB/La autoantibodies are common in HCV-infected individuals.
  • A significant negative association exists between anti-SSB/La antibodies and HLA-DR2 in this Taiwanese HCV cohort.

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