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Rheopheresis in vascular diseases.

M Ferrannini1, G Vischini, E Staffolani

  • 1Nephrology and Dialysis Unit, Tor Vergata University, Rome, Italy. m.ferrannini@inwind.it

The International Journal of Artificial Organs
|November 10, 2007
PubMed
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Rheopheresis therapy effectively treats microvascular diseases like Age-related Macular Degeneration and Peripheral Arterial Occlusive Disease. This hemorheotherapy improves patient outcomes with no observed adverse effects, enhancing visual acuity and healing ulcers.

Area of Science:

  • Cardiovascular Diseases
  • Ophthalmology
  • Nephrology

Background:

  • Endothelial dysfunction is a key factor in microvascular diseases like Age-related Macular Degeneration (AMD) and Peripheral Arterial Occlusive Disease (PAOD).
  • Rheopheresis therapy is a hemorheotherapy that modifies blood rheology and improves endothelial function.

Purpose of the Study:

  • To evaluate the therapeutic efficacy of rheopheresis in patients suffering from microcirculatory diseases.
  • Assessing the impact of rheopheresis on visual acuity in AMD patients and ulcer healing in PAOD patients.

Main Methods:

  • Eight patients (3 with AMD, 5 with PAOD/uremia) underwent rheopheresis using Membrane Differential Filtration (MDF).
  • Treatment protocols varied: weekly for AMD patients over ten weeks, and twice-weekly for three weeks followed by weekly sessions for PAOD patients.

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Main Results:

  • Significant improvement in visual acuity was observed in all treated AMD patients.
  • Complete pain resolution and ulcer remission in 3 out of 5 PAOD patients; partial remission in others.
  • No adverse effects were reported during the rheopheresis treatment.

Conclusions:

  • Rheopheresis is a safe and effective hemorheotherapy for microvascular conditions.
  • The study demonstrates positive clinical outcomes for patients with AMD and PAOD treated with rheopheresis.