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Updated: Jul 10, 2026

Viral Transgene Expression in Rodent Hearts and the Assessment of Cardiac Arrhythmia Risk
Published on: July 27, 2022
Gene therapy approaches to ventricular tachyarrhythmias
J Kevin Donahue1, Tetsuo Sasano, Kamilla Kelemen
1Heart and Vascular Research Center, MetroHealth Campus, Case Western Reserve University, Cleveland, OH, USA. kdonahue@metrohealth.org
Abstract:
Ventricular tachycardia arising from a healed myocardial infarction scar continues to be a significant cause of morbidity and mortality. Drug therapy has been inadequate to meet this challenge, and implantable devices are limited by expense and technical problems. We have proposed the use of gene therapy for cardiac arrhythmias. In this review, we present a model of postinfarct ventricular tachycardia, a method for gene delivery to this area, and results of KCNH2-G628S gene transfer to manipulate cellular refractory properties in the arrhythmia model.
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