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Interaction of Bacillus subtilis CodY with GTP

Luke D Handke1, Robert P Shivers, Abraham L Sonenshein

  • 1Department of Molecular Biology and Microbiology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA.

Journal of Bacteriology
|November 13, 2007
PubMed
Summary

Bacillus subtilis adaptation relies on CodY, a protein regulated by GTP and branched-chain amino acids (BCAAs). CodY specifically binds GTP, enhancing its DNA affinity without hydrolysis, especially when BCAAs are also present.

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