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Related Concept Videos

Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
Genome Annotation and Assembly03:36

Genome Annotation and Assembly

The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes02:16

Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes

The present-day mitochondrial and chloroplast genomes have retained some of the characteristics of their ancestral prokaryotes and also have acquired new attributes during their evolution within eukaryotic cells. Like prokaryotic genomes, mitochondrial and chloroplast genomes neither bind with histone-like proteins nor show complex packaging into chromosome-like structures, as observed in eukaryotes. Unlike mitotic cell divisions observed in eukaryotic cells, mitochondria and chloroplasts...
Comparing Copy Number Variations and SNPs02:26

Comparing Copy Number Variations and SNPs

Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
Next-generation Sequencing03:00

Next-generation Sequencing

The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.

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Related Experiment Video

Updated: Jul 10, 2026

An Integrated Approach for Microprotein Identification and Sequence Analysis
09:37

An Integrated Approach for Microprotein Identification and Sequence Analysis

Published on: July 12, 2022

Comparative analysis and visualization of genomic sequences using VISTA browser and associated computational tools.

Inna Dubchak1

  • 1Lawrence Berkeley National Laboratory, USA.

Methods in Molecular Biology (Clifton, N.J.)
|November 13, 2007
PubMed
Summary

The VISTA Browser offers interactive tools for visualizing and analyzing genomic alignments. This computational platform aids biologists in exploring large-scale sequence data and understanding evolutionary relationships.

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Area of Science:

  • Genomics
  • Bioinformatics
  • Computational Biology

Background:

  • The rapid increase in genomic data necessitates advanced computational tools for analysis.
  • Comparative genomics requires efficient methods for sequence alignment and visualization.
  • Interactive data exploration is crucial for biological insights.

Purpose of the Study:

  • To describe the VISTA Browser and its computational tools for genomic alignment analysis.
  • To highlight the importance of visualization in comparative genomics.
  • To showcase the capabilities of VISTA for exploring DNA sequences and whole genomes.

Main Methods:

  • Utilizing the VISTA Browser for interactive visual exploration of genomic alignments.
  • Applying associated computational tools for sequence analysis.
  • Examining alignments of eukaryotic and microbial genomes.

Main Results:

  • Demonstration of VISTA Browser's rich capabilities for analyzing genomic data.
  • Examples of successful examination of DNA sequence and whole genome alignments.
  • Accessibility of VISTA tools through the VISTA portal.

Conclusions:

  • The VISTA Browser provides essential interactive visualization for genomic alignment analysis.
  • Effective tools like VISTA facilitate in-depth investigation of complex genomic datasets.
  • VISTA supports the exploration of evolutionary relationships and functional elements across diverse genomes.