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Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

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Published on: August 15, 2019

Aligning multiple whole genomes with Mercator and MAVID.

Colin N Dewey¹

¹Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, USA.

Methods in Molecular Biology (Clifton, N.J.)

|November 13, 2007

Summary

Researchers can now perform whole-genome alignments quickly using Mercator and MAVID. This tutorial guides users through nucleotide-level multiple alignment of multiple whole genomes on a single laptop.

Area of Science:

Bioinformatics
Computational Biology
Genomics

Background:

The increasing volume of whole genome sequences necessitates efficient alignment tools.
Existing methods may not be suitable for rapid, large-scale genome alignment.

Purpose of the Study:

To present a tutorial for performing nucleotide-level multiple whole genome alignments.
To introduce the combined use of Mercator and MAVID for efficient genome alignment.

Main Methods:

Utilizing Mercator to generate an orthology map from multiple whole genomes.
Employing MAVID for nucleotide-level multiple alignments guided by the Mercator orthology map.

Main Results:

Mercator and MAVID provide a fast and accessible solution for whole genome alignment.

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The combined approach enables genome alignment on a single laptop.

Conclusions:

The Mercator-MAVID pipeline offers a practical and efficient method for researchers to conduct whole genome alignments.
This tutorial facilitates the adoption of these tools for genomic research.