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Microscale Vortex-assisted Electroporator for Sequential Molecular Delivery
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Electrosonic ejector microarray for drug and gene delivery.

Vladimir G Zarnitsyn1, J Mark Meacham, Mark J Varady

  • 1George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, 771 Ferst Dr., Atlanta, GA 30302, USA.

Biomedical Microdevices
|November 13, 2007
PubMed
Summary
This summary is machine-generated.

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We developed an electrosonic ejector microarray for precise cell manipulation and drug/gene delivery. This novel device uses focused ultrasound to control biophysical action on individual cells, enabling targeted cellular bioeffects.

Area of Science:

  • Biotechnology
  • Cell Biology
  • Bioengineering

Background:

  • Traditional drug and gene delivery methods often lack precision at the cellular level.
  • Controlling biophysical forces on individual cells is crucial for targeted cellular manipulation.
  • Existing technologies may not offer scalable and economical solutions for single-cell level interventions.

Purpose of the Study:

  • To develop and characterize a novel electrosonic ejector microarray for precise cell manipulation.
  • To establish a pathway for controlled drug and/or gene delivery at the single-cell scale.
  • To investigate the biophysical mechanisms underlying cell manipulation using focused ultrasound.

Main Methods:

  • Development of an electrosonic ejector microarray with piezoelectric transducer and acoustic horn structures.

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  • Micromachining of nozzle arrays in silicon or plastic for focused mechanical energy application.
  • Experimental characterization of cell manipulation, including calcein uptake and GFP gene transfection in glioma cells.

    • Main Results:

    • Demonstrated successful calcein uptake and DNA plasmid (GFP) transfection into human malignant glioma cells.
    • Utilized electrosonic microarrays with varying nozzle orifice sizes (36, 45, 50 µm) and ultrasound frequencies (0.91–0.98 MHz).
    • Showcased control over cellular bioeffects, including molecule uptake and gene delivery, through nozzle size and acoustic field intensity.

    Conclusions:

    • The electrosonic ejector microarray offers a novel approach for precise cell manipulation and delivery.
    • Nozzle orifice size and acoustic field intensity are key factors controlling the efficacy of cellular bioeffects.
    • This technology holds potential for advancing drug and gene delivery applications with single-cell control.